Management of a patient with schizophrenia and underlying pituitary macroadenoma.

نویسندگان

  • Kah Wee Ng
  • Jimmy Lee
  • Verma Swapna
چکیده

Dear Editor, Hyperprolactinemia was found to be prevalent in a multi-centred study of 402 patients with schizophrenia, schizoaffective disorder and schizophreniform disorder treated with conventional antipsychotics and Risperidone.1 Antipsychotics inhibit the dopamine receptors and induce hyperprolactinemia via the tubulo-infundibular pathway, with subsequent downstream effects on multiple systems. Hyperprolactinemia brings about reduction in oestrogen and testosterone, causing bone resorption and reduced bone mineral density. Hyperprolactinemia in women causes lowered oestrogen and nitric oxide levels, with a consequent elevation of blood pressure. Hyperprolactinemia causes diminished sexual drive and menstrual irregularities, and may increase a person’s risk of developing breast cancer. The following case report will focus on the management of a patient with schizophrenia and underlying pituitary macroadenoma with hyperprolactinemia.

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عنوان ژورنال:
  • Annals of the Academy of Medicine, Singapore

دوره 39 11  شماره 

صفحات  -

تاریخ انتشار 2010